Molecular analysis of urothelial cancer cell lines for modeling tumor biology and drug response

The utility of tumor-derived cell lines is dependent on their ability to recapitulate underlying genomic aberrations and primary tumor biology. Here, we sequenced the exomes of 25 bladder cancer (BCa) cell lines and compared mutations, copy number alterations (CNAs), gene expression and drug respons...

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Detalhes bibliográficos
Publicado no:Oncogene
Main Authors: Nickerson, M L, Witte, N, Im, K M, Turan, S, Owens, C, Misner, K, Tsang, S X, Cai, Z, Wu, S, Dean, M, Costello, J C, Theodorescu, D
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2017
Assuntos:
Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5140783/
https://ncbi.nlm.nih.gov/pubmed/27270441
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2016.172
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