Role of rare variants in undetermined multiple adenomatous polyposis and early-onset colorectal cancer

Some 15–20% of multiple adenomatous polyposis have no genetic explanation and 20–30% of colorectal cancer (CRC) cases are thought to be due to inherited multifactorial causes. Accumulation of deleterious effects of low-frequency dominant and independently acting variants may be a partial explanation...

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Bibliografski detalji
Izdano u:J Hum Genet
Glavni autori: Lefevre, Jérémie H, Bonilla, Carolina, Colas, Chrystelle, Winney, Bruce, Johnstone, Elaine, Tonks, Susan, Day, Tammy, Hutnik, Katarzyna, Boumertit, Abdelhamid, Soubrier, Florent, Midgley, Rachel, Kerr, David, Parc, Yann, Bodmer, Walter F
Format: Artigo
Jezik:Inglês
Izdano: 2012
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Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5140019/
https://ncbi.nlm.nih.gov/pubmed/22875147
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/jhg.2012.99
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