Frequent Somatic Mutation in Adult Intestinal Stem Cells Drives Neoplasia and Genetic Mosaicism during Aging

Adult stem cells may acquire mutations that modify cellular behavior, leading to functional declines in homeostasis or providing a competitive advantage resulting in premalignancy. However, the frequency, phenotypic impact, and mechanisms underlying spontaneous mutagenesis during aging are unclear....

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Detaylı Bibliyografya
Yayımlandı:Cell Stem Cell
Asıl Yazarlar: Siudeja, Katarzyna, Nassari, Sonya, Gervais, Louis, Skorski, Patricia, Lameiras, Sonia, Stolfa, Donato, Zande, Maria, Bernard, Virginie, Frio, Thomas Rio, Bardin, Allison J.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Cell Press 2015
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Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5138153/
https://ncbi.nlm.nih.gov/pubmed/26607382
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stem.2015.09.016
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