Density of immunogenic antigens does not explain the presence or absence of the T-cell–inflamed tumor microenvironment in melanoma

Melanoma metastases can be categorized by gene expression for the presence of a T-cell–inflamed tumor microenvironment, which correlates with clinical efficacy of immunotherapies. T cells frequently recognize mutational antigens corresponding to nonsynonymous somatic mutations (NSSMs), and in some c...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Spranger, Stefani, Luke, Jason J., Bao, Riyue, Zha, Yuanyuan, Hernandez, Kyle M., Li, Yan, Gajewski, Alexander P., Andrade, Jorge, Gajewski, Thomas F.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2016
Assuntos:
PNAS Plus
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5137753/
https://ncbi.nlm.nih.gov/pubmed/27837020
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1609376113
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