Interactions of mucins with the Tn or Sialyl Tn cancer antigens including MUC1 are due to GalNAc–GalNAc interactions

The molecular mechanism(s) underlying the enhanced self-interactions of mucins possessing the Tn (GalNAcα1-Ser/Thr) or STn (NeuNAcα2-6GalNAcα1-Ser/Thr) cancer markers were investigated using optical tweezers (OT). The mucins examined included modified porcine submaxillary mucin containing the Tn epi...

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Publicat a:Glycobiology
Autors principals: Haugstad, Kristin E, Hadjialirezaei, Soosan, Stokke, Bjørn T, Brewer, C Fred, Gerken, Thomas A, Burchell, Joy, Picco, Gianfranco, Sletmoen, Marit
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2016
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Original articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5137250/
https://ncbi.nlm.nih.gov/pubmed/27282157
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/glycob/cww065
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