Multimodal Regulation of NET Formation in Pregnancy: Progesterone Antagonizes the Pro-NETotic Effect of Estrogen and G-CSF

Human pregnancy is associated with a mild pro-inflammatory state, characterized by circulatory neutrophil activation. In order to explore the mechanism underlying this alteration, we examined NETosis during normal gestation. Our data indicate that neutrophils exhibit a pro-NETotic state, modulated i...

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Vydáno v:Front Immunol
Hlavní autoři: Giaglis, Stavros, Stoikou, Maria, Sur Chowdhury, Chanchal, Schaefer, Guenther, Grimolizzi, Franco, Rossi, Simona W., Hoesli, Irene Mathilde, Lapaire, Olav, Hasler, Paul, Hahn, Sinuhe
Médium: Artigo
Jazyk:Inglês
Vydáno: Frontiers Media S.A. 2016
Témata:
Immunology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5136684/
https://ncbi.nlm.nih.gov/pubmed/27994595
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2016.00565
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