Cigarette Smoke Induction of Interleukin-27/WSX-1 Regulates the Differentiation of Th1 and Th17 Cells in a Smoking Mouse Model of Emphysema

IFN-γ-producing CD4(+) T (Th1) cells and IL-17-producing CD4(+) T (Th17) cells play a critical role in the pathogenesis of chronic obstructive pulmonary disease (COPD). However, the immune regulation between Th1 and Th17 cells remains unclear. Previous studies have demonstrated that interleukin-27 (...

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Bibliographische Detailangaben
Veröffentlicht in:Front Immunol
Hauptverfasser: Qiu, Shi-Lin, Duan, Min-Chao, Liang, Yi, Tang, Hai-Juan, Liu, Guang-Nan, Zhang, Liang-Ming, Yang, Chao-Mian
Format: Artigo
Sprache:Inglês
Veröffentlicht: Frontiers Media S.A. 2016
Schlagworte:
Immunology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5136545/
https://ncbi.nlm.nih.gov/pubmed/27994590
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2016.00553
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