Hopeahainol A binds reversibly at the acetylcholinesterase (AChE) peripheral site and inhibits enzyme activity with a novel higher order concentration dependence

Natural product inhibitors of AChE are of interest both because they offer promise as inexpensive drugs for symptomatic relief in Alzheimer’s disease and because they may provide insights into the structural features of the AChE catalytic site. Hopeahainol A is an uncharged polyphenol AChE inhibitor...

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Bibliografiska uppgifter
I publikationen:Chem Biol Interact
Huvudupphovsmän: Rosenberry, Terrone L., Martin, Patricia K., Nix, A. Jeremy, Wildman, Scott A., Cheung, Jonah, Snyder, Scott A., Tan, Ren Xiang
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2016
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5136322/
https://ncbi.nlm.nih.gov/pubmed/27297626
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cbi.2016.05.032
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