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Lidocaine relaxation in isolated rat aortic rings is enhanced by endothelial removal: possible role of K(v), K(ATP) channels and A(2a) receptor crosstalk

BACKGROUND: Lidocaine is an approved local anesthetic and Class 1B antiarrhythmic with a number of ancillary properties. Our aim was to investigate lidocaine’s vasoreactivity properties in intact versus denuded rat thoracic aortic rings, and the effect of inhibitors of nitric oxide (NO), prostenoids...

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Detalhes bibliográficos
Publicado no:BMC Anesthesiol
Main Authors: Arsyad, Aryadi, Dobson, Geoffrey P.
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5135802/
https://ncbi.nlm.nih.gov/pubmed/27914476
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12871-016-0286-y
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