HIF-KDM3A-MMP12 regulatory circuit ensures trophoblast plasticity and placental adaptations to hypoxia

The hemochorial placenta develops from the coordinated multilineage differentiation of trophoblast stem (TS) cells. An invasive trophoblast cell lineage remodels uterine spiral arteries, facilitating nutrient flow, failure of which is associated with pathological conditions such as preeclampsia, int...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Chakraborty, Damayanti, Cui, Wei, Rosario, Gracy X., Scott, Regan L., Dhakal, Pramod, Renaud, Stephen J., Tachibana, Makoto, Rumi, M. A. Karim, Mason, Clifford W., Krieg, Adam J., Soares, Michael J.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2016
Assuntos:
PNAS Plus
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5135375/
https://ncbi.nlm.nih.gov/pubmed/27807143
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1612626113
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