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Modelling GTPase dynamics to understand RhoA-driven cancer cell invasion

Metastasis, initially driven by cells migrating and invading through the local environment, leads to most cancer-associated deaths. Cells can use a variety of modes to move in vitro, all of which depend on Rho GTPases at some level. While traditionally it was thought that Rac1 activity drives protru...

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Bibliographische Detailangaben
Veröffentlicht in:Biochem Soc Trans
Hauptverfasser: Hetmanski, Joseph H.R., Schwartz, Jean-Marc, Caswell, Patrick T.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Portland Press Ltd. 2016
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5134997/
https://ncbi.nlm.nih.gov/pubmed/27913679
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BST20160184
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