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Genetic determinants of P2Y12 inhibitors and clinical implications
There is significant inter-patient variability in clopidogrel effectiveness, which is due in part to cytochrome P450 (CYP) 2C19 genotype. Approximately 30% of individuals carry CYP2C19 loss-of-function (LOF) alleles, which have been consistently shown to reduce clopidogrel effectiveness after an acu...
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| Pubblicato in: | Interv Cardiol Clin |
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| Autori principali: | , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2017
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5134418/ https://ncbi.nlm.nih.gov/pubmed/27886818 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.iccl.2016.08.010 |
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