Dopamine-2 receptor extracellular N-terminus regulates receptor surface availability and is the target of human pathogenic antibodies from children with movement and psychiatric disorders

Anti-Dopamine-2 receptor (D2R) antibodies have been recently identified in a subgroup of children with autoimmune movement and psychiatric disorders, however the epitope(s) and mechanism of pathogenicity remain unknown. Here we report a major biological role for D2R extracellular N-terminus as a reg...

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Detalhes bibliográficos
Publicado no:Acta Neuropathol Commun
Main Authors: Sinmaz, Nese, Tea, Fiona, Pilli, Deepti, Zou, Alicia, Amatoury, Mazen, Nguyen, Tina, Merheb, Vera, Ramanathan, Sudarshini, Cooper, Sandra T., Dale, Russell C., Brilot, Fabienne
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2016
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5134269/
https://ncbi.nlm.nih.gov/pubmed/27908295
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40478-016-0397-1
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