DDX3 DEAD-box RNA helicase plays a central role in mitochondrial protein quality control in Leishmania

DDX3 is a highly conserved member of ATP-dependent DEAD-box RNA helicases with multiple functions in RNA metabolism and cellular signaling. Here, we describe a novel function for DDX3 in regulating the mitochondrial stress response in the parasitic protozoan Leishmania. We show that genetic inactiva...

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Publicado no:Cell Death Dis
Main Authors: Padmanabhan, Prasad Kottayil, Zghidi-Abouzid, Ouafa, Samant, Mukesh, Dumas, Carole, Aguiar, Bruno Guedes, Estaquier, Jerome, Papadopoulou, Barbara
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5133982/
https://ncbi.nlm.nih.gov/pubmed/27735940
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2016.315
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