DDX3 DEAD-box RNA helicase plays a central role in mitochondrial protein quality control in Leishmania

DDX3 is a highly conserved member of ATP-dependent DEAD-box RNA helicases with multiple functions in RNA metabolism and cellular signaling. Here, we describe a novel function for DDX3 in regulating the mitochondrial stress response in the parasitic protozoan Leishmania. We show that genetic inactiva...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Cell Death Dis
Prif Awduron: Padmanabhan, Prasad Kottayil, Zghidi-Abouzid, Ouafa, Samant, Mukesh, Dumas, Carole, Aguiar, Bruno Guedes, Estaquier, Jerome, Papadopoulou, Barbara
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Nature Publishing Group 2016
Pynciau:
Original Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5133982/
https://ncbi.nlm.nih.gov/pubmed/27735940
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2016.315
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