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p53 Proteoforms and Intrinsic Disorder: An Illustration of the Protein Structure–Function Continuum Concept

Although it is one of the most studied proteins, p53 continues to be an enigma. This protein has numerous biological functions, possesses intrinsically disordered regions crucial for its functionality, can form both homo-tetramers and isoform-based hetero-tetramers, and is able to interact with many...

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Detalles Bibliográficos
Publicado en:Int J Mol Sci
Autor Principal: Uversky, Vladimir N.
Formato: Artigo
Idioma:Inglês
Publicado: MDPI 2016
Assuntos:
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5133874/
https://ncbi.nlm.nih.gov/pubmed/27834926
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms17111874
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