IL-12 protects from psoriasiform skin inflammation

Neutralization of the common p40-subunit of IL-12/23 in psoriasis patients has led to a breakthrough in the management of moderate to severe disease. Aside from neutralizing IL-23, which is thought to be responsible for the curative effect, anti-p40 therapy also interferes with IL-12 signalling and...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Kulig, Paulina, Musiol, Stephanie, Freiberger, Sandra Nicole, Schreiner, Bettina, Gyülveszi, Gabor, Russo, Giancarlo, Pantelyushin, Stanislav, Kishihara, Kenji, Alessandrini, Francesca, Kündig, Thomas, Sallusto, Federica, Hofbauer, Günther F.L., Haak, Stefan, Becher, Burkhard
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5133729/
https://ncbi.nlm.nih.gov/pubmed/27892456
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms13466
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