A redox mechanism underlying nucleolar stress sensing by nucleophosmin

The nucleolus has been recently described as a stress sensor. The nucleoplasmic translocation of nucleolar protein nucleophosmin (NPM1) is a hallmark of nucleolar stress; however, the causes of this translocation and its connection to p53 activation are unclear. Using single live-cell imaging and th...

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Veröffentlicht in:Nat Commun
Hauptverfasser: Yang, Kai, Wang, Ming, Zhao, Yuzheng, Sun, Xuxu, Yang, Yi, Li, Xie, Zhou, Aiwu, Chu, Huilin, Zhou, Hu, Xu, Jianrong, Wu, Mian, Yang, Jie, Yi, Jing
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2016
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5133708/
https://ncbi.nlm.nih.gov/pubmed/27886181
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms13599
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