Genome-wide RNAi screening identifies TMIGD3 isoform1 as a suppressor of NF-κB and osteosarcoma progression

The ability of cancer cells to survive and grow in anchorage- and serum-independent conditions is well correlated with their aggressiveness. Here, using a human whole-genome shRNA library, we identify TMIGD3 isoform1 (i1) as a factor that suppresses this ability in osteosarcoma (OS) cells, mainly by...

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Veröffentlicht in:Nat Commun
Hauptverfasser: Iyer, Swathi V., Ranjan, Atul, Elias, Harold K., Parrales, Alejandro, Sasaki, Hiromi, Roy, Badal C., Umar, Shahid, Tawfik, Ossama W., Iwakuma, Tomoo
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2016
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5133659/
https://ncbi.nlm.nih.gov/pubmed/27886186
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms13561
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