Impact of Perturbed Pancreatic β-Cell Cholesterol Homeostasis on Adipose Tissue and Skeletal Muscle Metabolism

Elevated pancreatic β-cell cholesterol levels impair insulin secretion and reduce plasma insulin levels. This study establishes that low plasma insulin levels have a detrimental effect on two major insulin target tissues: adipose tissue and skeletal muscle. Mice with increased β-cell cholesterol lev...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:Diabetes
Päätekijät: Cochran, Blake J., Hou, Liming, Manavalan, Anil Paul Chirackal, Moore, Benjamin M., Tabet, Fatiha, Sultana, Afroza, Cuesta Torres, Luisa, Tang, Shudi, Shrestha, Sudichhya, Senanayake, Praween, Patel, Mili, Ryder, William J., Bongers, Andre, Maraninchi, Marie, Wasinger, Valerie C., Westerterp, Marit, Tall, Alan R., Barter, Philip J., Rye, Kerry-Anne
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: American Diabetes Association 2016
Aiheet:
Metabolism
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC5132410/
https://ncbi.nlm.nih.gov/pubmed/27702832
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db16-0668
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