Impact of Perturbed Pancreatic β-Cell Cholesterol Homeostasis on Adipose Tissue and Skeletal Muscle Metabolism

Elevated pancreatic β-cell cholesterol levels impair insulin secretion and reduce plasma insulin levels. This study establishes that low plasma insulin levels have a detrimental effect on two major insulin target tissues: adipose tissue and skeletal muscle. Mice with increased β-cell cholesterol lev...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
में प्रकाशित:Diabetes
मुख्य लेखकों: Cochran, Blake J., Hou, Liming, Manavalan, Anil Paul Chirackal, Moore, Benjamin M., Tabet, Fatiha, Sultana, Afroza, Cuesta Torres, Luisa, Tang, Shudi, Shrestha, Sudichhya, Senanayake, Praween, Patel, Mili, Ryder, William J., Bongers, Andre, Maraninchi, Marie, Wasinger, Valerie C., Westerterp, Marit, Tall, Alan R., Barter, Philip J., Rye, Kerry-Anne
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: American Diabetes Association 2016
विषय:
Metabolism
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC5132410/
https://ncbi.nlm.nih.gov/pubmed/27702832
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db16-0668
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