Mapping Cholesterol Interaction Sites on Serotonin Transporter through Coarse-Grained Molecular Dynamics

Serotonin transporter (SERT) modulates serotonergic signaling via re-uptake of serotonin in pre-synaptic cells. The inclusion in cholesterol-enriched membrane domains is crucial for SERT activity, suggesting a cross-talk between the protein and the sterol. Here, we develop a protocol to identify pot...

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Bibliografiska uppgifter
I publikationen:PLoS One
Huvudupphovsmän: Ferraro, Mariarosaria, Masetti, Matteo, Recanatini, Maurizio, Cavalli, Andrea, Bottegoni, Giovanni
Materialtyp: Artigo
Språk:Inglês
Publicerad: Public Library of Science 2016
Ämnen:
Research Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5132266/
https://ncbi.nlm.nih.gov/pubmed/27907003
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0166196
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