Mapping Cholesterol Interaction Sites on Serotonin Transporter through Coarse-Grained Molecular Dynamics

Serotonin transporter (SERT) modulates serotonergic signaling via re-uptake of serotonin in pre-synaptic cells. The inclusion in cholesterol-enriched membrane domains is crucial for SERT activity, suggesting a cross-talk between the protein and the sterol. Here, we develop a protocol to identify pot...

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Udgivet i:PLoS One
Main Authors: Ferraro, Mariarosaria, Masetti, Matteo, Recanatini, Maurizio, Cavalli, Andrea, Bottegoni, Giovanni
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2016
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5132266/
https://ncbi.nlm.nih.gov/pubmed/27907003
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0166196
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