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Astrocytes mediate neurovascular signaling to capillary pericytes but not to arterioles

Active neurons increase their energy supply by dilating nearby arterioles and capillaries. This neurovascular coupling underlies BOLD functional imaging signals, but its mechanism is controversial. Canonically, neurons release glutamate to activate metabotropic glutamate receptors (mGluR5) on astroc...

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Bibliographische Detailangaben
Veröffentlicht in:Nat Neurosci
Hauptverfasser: Mishra, Anusha, Reynolds, James P., Chen, Yang, Gourine, Alexander V., Rusakov, Dmitri A., Attwell, David
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2016
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5131849/
https://ncbi.nlm.nih.gov/pubmed/27775719
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nn.4428
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