Intramyocellular ceramides and skeletal muscle mitochondrial respiration are partially regulated by Toll-like receptor 4 during hindlimb unloading

Physical inactivity and disuse result in skeletal muscle metabolic disruption, including insulin resistance and mitochondrial dysfunction. The role of the Toll-like receptor 4 (TLR4) signaling pathway in contributing to metabolic decline with muscle disuse is unknown. Therefore, our goal was to dete...

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Bibliographic Details
Published in:Am J Physiol Regul Integr Comp Physiol
Main Authors: Kwon, Oh Sung, Nelson, Daniel S., Barrows, Katherine M., O'Connell, Ryan M., Drummond, Micah J.
Format: Artigo
Language:Inglês
Published: American Physiological Society 2016
Subjects:
Physical Activity and Inactivity
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5130578/
https://ncbi.nlm.nih.gov/pubmed/27581814
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpregu.00253.2016
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