Selective Inhibitor of Nuclear Export (SINE) Compounds Alter New World Alphavirus Capsid Localization and Reduce Viral Replication in Mammalian Cells

The capsid structural protein of the New World alphavirus, Venezuelan equine encephalitis virus (VEEV), interacts with the host nuclear transport proteins importin α/β1 and CRM1. Novel selective inhibitor of nuclear export (SINE) compounds, KPT-185, KPT-335 (verdinexor), and KPT-350, target the host...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:PLoS Negl Trop Dis
Main Authors: Lundberg, Lindsay, Pinkham, Chelsea, de la Fuente, Cynthia, Brahms, Ashwini, Shafagati, Nazly, Wagstaff, Kylie M., Jans, David A., Tamir, Sharon, Kehn-Hall, Kylene
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5130180/
https://ncbi.nlm.nih.gov/pubmed/27902702
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pntd.0005122
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados