A Novel Zebrafish ret Heterozygous Model of Hirschsprung Disease Identifies a Functional Role for mapk10 as a Modifier of Enteric Nervous System Phenotype Severity

Hirschsprung disease (HSCR) is characterized by absence of enteric neurons from the distal colon and severe intestinal dysmotility. To understand the pathophysiology and genetics of HSCR we developed a unique zebrafish model that allows combined genetic, developmental and in vivo physiological studi...

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Bibliografske podrobnosti
izdano v:PLoS Genet
Main Authors: Heanue, Tiffany A., Boesmans, Werend, Bell, Donald M., Kawakami, Koichi, Vanden Berghe, Pieter, Pachnis, Vassilis
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2016
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5130169/
https://ncbi.nlm.nih.gov/pubmed/27902697
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1006439
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