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Interference with mutagenic aflatoxin B1-induced checkpoints through antagonistic action of ochratoxin A in intestinal cancer cells: a molecular explanation on potential risk of crosstalk between carcinogens
Foodborne aflatoxin B(1) (AFB(1)) and ochratoxin A (OTA) cause genotoxic injury and subsequent tumor formation. As a biomarker of oncogenic stimulation by genotoxic mycotoxins, p53-triggered Mdm2 was assessed in intestinal cancer cells. AFB(1) increased Mdm2 reporter expression in a dose-dependent m...
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| Izdano u: | Oncotarget |
|---|---|
| Glavni autori: | , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
Impact Journals LLC
2016
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5129958/ https://ncbi.nlm.nih.gov/pubmed/27119350 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.8914 |
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