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Anti-Tac-H, a humanized antibody to the interleukin 2 receptor, prolongs primate cardiac allograft survival.

High-affinity interleukin 2 receptors (IL-2Rs) are expressed by T cells activated in response to foreign histocompatibility antigens but not by normal resting T cells. To exploit this difference in IL-2R expression, anti-Tac-M, a murine monoclonal antibody specific for the IL-2R alpha chain, was use...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Brown, P S, Parenteau, G L, Dirbas, F M, Garsia, R J, Goldman, C K, Bukowski, M A, Junghans, R P, Queen, C, Hakimi, J, Benjamin, W R
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 1991
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC51298/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2011577/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.88.7.2663
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