Conversion of the interleukin 1 receptor antagonist into an agonist by site-specific mutagenesis.

Interleukin 1 (IL-1) receptor antagonist (IL-1ra) is a naturally occurring protein that binds to the IL-1 receptor present on T cells, fibroblasts, and other cell types and acts to block IL-1-induced responses. IL-1ra is a pure antagonist and has no agonist activity in in vitro or in vivo systems. B...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Ju, G, Labriola-Tompkins, E, Campen, C A, Benjamin, W R, Karas, J, Plocinski, J, Biondi, D, Kaffka, K L, Kilian, P L, Eisenberg, S P
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1991
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC51297/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1826365/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.88.7.2658
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