Robust anti‐obesity and metabolic effects of a dual GLP‐1/glucagon receptor peptide agonist in rodents and non‐human primates

AIMS: To characterize the pharmacology of MEDI0382, a peptide dual agonist of glucagon‐like peptide‐1 (GLP‐1) and glucagon receptors. MATERIALS AND METHODS: MEDI0382 was evaluated in vitro for its ability to stimulate cAMP accumulation in cell lines expressing transfected recombinant or endogenous G...

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Bibliografske podrobnosti
izdano v:Diabetes Obes Metab
Main Authors: Henderson, S. J., Konkar, A., Hornigold, D. C., Trevaskis, J. L., Jackson, R., Fritsch Fredin, M., Jansson‐Löfmark, R., Naylor, J., Rossi, A., Bednarek, M. A., Bhagroo, N., Salari, H., Will, S., Oldham, S., Hansen, G., Feigh, M., Klein, T., Grimsby, J., Maguire, S., Jermutus, L., Rondinone, C. M., Coghlan, M. P.
Format: Artigo
Jezik:Inglês
Izdano: Blackwell Publishing Ltd 2016
Teme:
Original Articles
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5129521/
https://ncbi.nlm.nih.gov/pubmed/27377054
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/dom.12735
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