Sequence diversity of dengue virus type 2 in brain and thymus of infected interferon receptor ko mice: implications for dengue virulence

BACKGROUND: We previously reported that a clinical isolate of dengue virus (DENV) is capable of causing acute-phase systemic infection in mice harboring knockouts of the genes encoding type-I and -II interferon IFN receptors (IFN-α/β/γR KO mice); in contrast, other virulent DENV isolates exhibited s...

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Detalles Bibliográficos
Publicado en:Virol J
Main Authors: Dhole, Priya, Nakayama, Emi E., Saito, Akatsuki, Limkittikul, Kriengsak, Phanthanawiboon, Supranee, Shioda, Tatsuo, Kurosu, Takeshi
Formato: Artigo
Idioma:Inglês
Publicado: BioMed Central 2016
Assuntos:
Research
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5129197/
https://ncbi.nlm.nih.gov/pubmed/27903277
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12985-016-0658-4
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