A six-amino acid deletion in basic fibroblast growth factor dissociates its mitogenic activity from its plasminogen activator-inducing capacity.

A recombinant deletion mutant of the 155-amino acid form of human basic fibroblast growth factor (bFGF), lacking amino acid residues 27-32 (Lys-Asp-Pro-Lys-Arg-Leu), was expressed in Escherichia coli and purified to homogeneity by heparin-Sepharose affinity chromatography. When maintained in the pre...

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Hauptverfasser: Isacchi, A, Statuto, M, Chiesa, R, Bergonzoni, L, Rusnati, M, Sarmientos, P, Ragnotti, G, Presta, M
Format: Artigo
Sprache:Inglês
Veröffentlicht: 1991
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC51291/
https://ncbi.nlm.nih.gov/pubmed/1849269
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