Rhein and rhubarb similarly protect the blood-brain barrier after experimental traumatic brain injury via gp91(phox) subunit of NADPH oxidase/ROS/ERK/MMP-9 signaling pathway

Oxidative stress chiefly contributes to the disruption of the BBB following traumatic brain injury (TBI). The Chinese herbal medicine rhubarb is a promising antioxidant in treating TBI. Here we performed in vivo and in vitro experiments to determine whether rhubarb and its absorbed bioactive compoun...

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Bibliografiske detaljer
Udgivet i:Sci Rep
Main Authors: Wang, Yang, Fan, Xuegong, Tang, Tao, Fan, Rong, Zhang, Chunhu, Huang, Zebing, Peng, Weijun, Gan, Pingping, Xiong, Xingui, Huang, Wei, Huang, Xi
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2016
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5128794/
https://ncbi.nlm.nih.gov/pubmed/27901023
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep37098
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