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Structure–Activity Relationship Studies Using Natural and Synthetic Okadaic Acid/Dinophysistoxin Toxins

Okadaic acid (OA) and the closely related dinophysistoxins (DTXs) are algal toxins that accumulate in shellfish and are known serine/threonine protein phosphatase (ser/thr PP) inhibitors. Phosphatases are important modulators of enzyme activity and cell signaling pathways. However, the interactions...

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Опубликовано в: :Mar Drugs
Главные авторы: Twiner, Michael J., Doucette, Gregory J., Pang, Yucheng, Fang, Chao, Forsyth, Craig J., Miles, Christopher O.
Формат: Artigo
Язык:Inglês
Опубликовано: MDPI 2016
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5128750/
https://ncbi.nlm.nih.gov/pubmed/27827901
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/md14110207
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