The Lack of Antitumor Effects of o,p′DDA Excludes Its Role as an Active Metabolite of Mitotane for Adrenocortical Carcinoma Treatment

Mitotane (o,p′DDD) is the most effective treatment of advanced adrenocortical carcinoma (ACC) but its mechanism of action remains unknown. Previous studies suggested that o,p′DDA may represent the active metabolite of mitotane. We aimed at reevaluating the potential role and pharmacological effects...

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Bibliographic Details
Published in:Horm Cancer
Main Authors: Hescot, Ségolène, Paci, Angelo, Seck, Atmane, Slama, Abdelhamid, Viengchareun, Say, Trabado, Séverine, Brailly-Tabard, Sylvie, Al Ghuzlan, Abir, Young, Jacques, Baudin, Eric, Lombès, Marc
Format: Artigo
Language:Inglês
Published: Springer US 2014
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Original Paper
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5127823/
https://ncbi.nlm.nih.gov/pubmed/25026941
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s12672-014-0189-7
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