Genotype-Dependent and Independent Calcium Signaling Dysregulation in Human Hypertrophic Cardiomyopathy

BACKGROUND: Aberrant calcium signaling may contribute to arrhythmias and adverse remodeling in hypertrophic cardiomyopathy (HCM). Mutations in sarcomere genes may distinctly alter calcium handling pathways. METHODS: We analyzed gene expression, protein levels, and functional assays for calcium regul...

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Udgivet i:Circulation
Main Authors: Helms, Adam S., Alvarado, Francisco J., Yob, Jaime, Tang, Vi T., Pagani, Francis, Russell, Mark W., Valdivia, Héctor H., Day, Sharlene M.
Format: Artigo
Sprog:Inglês
Udgivet: 2016
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5127749/
https://ncbi.nlm.nih.gov/pubmed/27688314
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCULATIONAHA.115.020086
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