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Inhibition of Carbamyl Phosphate Synthetase-I and Glutamine Synthetase by Hepatotoxic Doses of Acetaminophen in Mice

The primary mechanisms proposed for acetaminophen-induced hepatic necrosis should deplete protein thiols, either by covalent binding and thioether formation or by oxidative reactions such as S-thiolations. However, in previous studies we did not detect significant losses of protein thiol contents in...

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Detalhes bibliográficos
Publicado no:Toxicol Appl Pharmacol
Main Authors: Gupta, Sanjiv, Rogers, Lynette K., Taylor, Sarah K., Smith, Charles V.
Formato: Artigo
Idioma:Inglês
Publicado em: 1997
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5127704/
https://ncbi.nlm.nih.gov/pubmed/9344900
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1006/taap.1997.8228
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