Glyoxalase 1-knockdown in human aortic endothelial cells – effect on the proteome and endothelial function estimates

Methylglyoxal (MG), an arginine-directed glycating agent, is implicated in diabetic late complications. MG is detoxified by glyoxalase 1 (GLO1) of the cytosolic glyoxalase system. The aim was to investigate the effects of MG accumulation by GLO1-knockdown under hyperglycaemic conditions in human aor...

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Published in:Sci Rep
Main Authors: Stratmann, Bernd, Engelbrecht, Britta, Espelage, Britta C., Klusmeier, Nadine, Tiemann, Janina, Gawlowski, Thomas, Mattern, Yvonne, Eisenacher, Martin, Meyer, Helmut E., Rabbani, Naila, Thornalley, Paul J., Tschoepe, Diethelm, Poschmann, Gereon, Stühler, Kai
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2016
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5127188/
https://ncbi.nlm.nih.gov/pubmed/27898103
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep37737
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