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Prediction of reacting atoms for the major biotransformation reactions of organic xenobiotics

BACKGROUND: The knowledge of drug metabolite structures is essential at the early stage of drug discovery to understand the potential liabilities and risks connected with biotransformation. The determination of the site of a molecule at which a particular metabolic reaction occurs could be used as a...

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Detalhes bibliográficos
Publicado no:J Cheminform
Main Authors: Rudik, Anastasia V., Dmitriev, Alexander V., Lagunin, Alexey A., Filimonov, Dmitry A., Poroikov, Vladimir V.
Formato: Artigo
Idioma:Inglês
Publicado em: Springer International Publishing 2016
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5127045/
https://ncbi.nlm.nih.gov/pubmed/27994650
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13321-016-0183-x
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