Activation of WNT/β-Catenin Signaling Enhances Pancreatic Cancer Development and the Malignant Potential Via Up-regulation of Cyr61

Pancreatic ductal adenocarcinoma (PDAC), a poor prognostic cancer, commonly develops following activating mutations in the KRAS oncogene. Activation of WNT signaling is also commonly observed in PDAC. To ascertain the impact of postnatal activation of WNT-stimulated signaling pathways in PDAC develo...

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Udgivet i:Neoplasia
Main Authors: Sano, Makoto, Driscoll, David R., DeJesus-Monge, Wilfredo E., Quattrochi, Brian, Appleman, Victoria A., Ou, Jianhong, Zhu, Lihua Julie, Yoshida, Nao, Yamazaki, Shintaro, Takayama, Tadatoshi, Sugitani, Masahiko, Nemoto, Norimichi, Klimstra, David S., Lewis, Brian C.
Format: Artigo
Sprog:Inglês
Udgivet: Neoplasia Press 2016
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Original article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5126137/
https://ncbi.nlm.nih.gov/pubmed/27889647
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neo.2016.11.004
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