Genetic and epigenetic heterogeneity of epithelial ovarian cancer and the clinical implications for molecular targeted therapy

Epithelial ovarian cancer (EOC) is the most lethal gynaecological malignancy, and tumoural heterogeneity (TH) has been blamed for treatment failure. The genomic and epigenomic atlas of EOC varies significantly with tumour histotype, grade, stage, sensitivity to chemotherapy and prognosis. Rapidly ac...

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Vydáno v:J Cell Mol Med
Hlavní autoři: Bai, Huimin, Cao, Dongyan, Yang, Jiaxin, Li, Menghui, Zhang, Zhenyu, Shen, Keng
Médium: Artigo
Jazyk:Inglês
Vydáno: John Wiley and Sons Inc. 2016
Témata:
Review Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5125785/
https://ncbi.nlm.nih.gov/pubmed/26800494
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jcmm.12771
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