Restricted T-cell receptor V beta gene usage by myelin basic protein-specific T-cell clones in multiple sclerosis: predominant genes vary in individuals.

Recent studies in experimental autoimmune encephalomyelitis as a model for multiple sclerosis (MS) have demonstrated limited heterogeneity in T-cell antigen receptors (TCR) specific for myelin basic protein (MBP). To investigate restricted beta-chain variable-region (V beta) gene usage in humans, we...

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Pubblicato in:	Proc Natl Acad Sci U S A
Autori principali:	Ben-Nun, A, Liblau, R S, Cohen, L, Lehmann, D, Tournier-Lasserve, E, Rosenzweig, A, Zhang, J W, Raus, J C, Bach, M A
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	National Academy of Sciences 1991
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC51253/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1706524/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.88.6.2466
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