New Genome-Wide Algorithm Identifies Novel In-Vivo Expressed Mycobacterium Tuberculosis Antigens Inducing Human T-Cell Responses with Classical and Unconventional Cytokine Profiles

New strategies are needed to develop better tools to control TB, including identification of novel antigens for vaccination. Such Mtb antigens must be expressed during Mtb infection in the major target organ, the lung, and must be capable of eliciting human immune responses. Using genome-wide transc...

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Veröffentlicht in:Sci Rep
Hauptverfasser: Coppola, Mariateresa, van Meijgaarden, Krista E., Franken, Kees L. M. C., Commandeur, Susanna, Dolganov, Gregory, Kramnik, Igor, Schoolnik, Gary K., Comas, Inaki, Lund, Ole, Prins, Corine, van den Eeden, Susan J. F., Korsvold, Gro E., Oftung, Fredrik, Geluk, Annemieke, Ottenhoff, Tom H. M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2016
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5125271/
https://ncbi.nlm.nih.gov/pubmed/27892960
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep37793
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