The Effects of Peripheral and Central High Insulin on Brain Insulin Signaling and Amyloid-β in Young and Old APP/PS1 Mice

Hyperinsulinemia is a risk factor for late-onset Alzheimer's disease (AD). In vitro experiments describe potential connections between insulin, insulin signaling, and amyloid-β (Aβ), but in vivo experiments are needed to validate these relationships under physiological conditions. First, we per...

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Pubblicato in:J Neurosci
Autori principali: Stanley, Molly, Macauley, Shannon L., Caesar, Emily E., Koscal, Lauren J., Moritz, Will, Robinson, Grace O., Roh, Joseph, Keyser, Jennifer, Jiang, Hong, Holtzman, David M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Society for Neuroscience 2016
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Research Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5125227/
https://ncbi.nlm.nih.gov/pubmed/27852778
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.2119-16.2016
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