Complement Regulator FHR-3 Is Elevated either Locally or Systemically in a Selection of Autoimmune Diseases

The human complement factor H-related protein-3 (FHR-3) is a soluble regulator of the complement system. Homozygous cfhr3/1 deletion is a genetic risk factor for the autoimmune form of atypical hemolytic-uremic syndrome (aHUS), while also found to be protective in age-related macular degeneration (A...

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Detalhes bibliográficos
Publicado no:Front Immunol
Main Authors: Schäfer, Nicole, Grosche, Antje, Reinders, Joerg, Hauck, Stefanie M., Pouw, Richard B., Kuijpers, Taco W., Wouters, Diana, Ehrenstein, Boris, Enzmann, Volker, Zipfel, Peter F., Skerka, Christine, Pauly, Diana
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2016
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5124756/
https://ncbi.nlm.nih.gov/pubmed/27965669
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2016.00542
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