Roles of H3K27me2 and H3K27me3 Examined During Fate Specification of Embryonic Stem Cells

The Polycomb Repressive Complex 2 (PRC2) methylates lysine 27 of histone H3 (H3K27) through its catalytic subunit Ezh2. PRC2-mediated di- and tri-methylation (H3K27me2/me3) have been interchangeably associated with gene repression. However, it remains unclear whether these two degrees of H3K27 methy...

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Pubblicato in:Cell Rep
Autori principali: Juan, Aster H., Wang, Stan, Ko, Kyung Dae, Zare, Hossein, Tsai, Pei-Fang, Feng, Xuesong, Vivanco, Karinna O., Ascoli, Anthony M., Gutierrez-Cruz, Gustavo, Krebs, Jordan, Sidoli, Simone, Knight, Adam L., Pedersen, Roger A., Garcia, Benjamin A., Casellas, Rafael, Zou, Jizhong, Sartorelli, Vittorio
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2016
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5123747/
https://ncbi.nlm.nih.gov/pubmed/27783950
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2016.09.087
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