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Suzuki–Miyaura cross-coupling optimization enabled by automated feedback
An automated, droplet-flow microfluidic system explores and optimizes Pd-catalyzed Suzuki–Miyaura cross-coupling reactions. A smart optimal DoE-based algorithm is implemented to increase the turnover number and yield of the catalytic system considering both discrete variables—palladacycle and ligand...
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| Udgivet i: | React Chem Eng |
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| Main Authors: | , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Royal Society of Chemistry
2016
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5123644/ https://ncbi.nlm.nih.gov/pubmed/27928513 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c6re00153j |
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