Lowered H3K27me3 and DNA hypomethylation define poorly prognostic pediatric posterior fossa ependymomas

Childhood posterior fossa (PF) ependymomas cause substantial morbidity and mortality. These tumors lack recurrent genetic mutations but a subset of these ependymomas exhibit CpG-island (CpGi) hypermethylation (PF group A; PFA), implicating epigenetic alterations in their pathogenesis. Further, histo...

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Publicado no:Sci Transl Med
Main Authors: Bayliss, Jill, Mukherjee, Piali, Lu, Chao, Jain, Siddhant U., Chung, Chan, Martinez, Daniel, Sabari, Benjamin, Margol, Ashley S., Panwalkar, Pooja, Parolia, Abhijit, Pekmezci, Melike, McEachin, Richard C, Cieslik, Marcin, Tamrazi, Benita, Garcia, Benjamin A., La Rocca, Gaspare, Santi, Mariarita, Lewis, Peter W., Hawkins, Cynthia, Melnick, Ari, Allis, C. David, Thompson, Craig B., Chinnaiyan, Arul M., Judkins, Alexander R., Venneti, Sriram
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5123566/
https://ncbi.nlm.nih.gov/pubmed/27881822
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.aah6904
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