Large-scale benchmarking reveals false discoveries and count transformation sensitivity in 16S rRNA gene amplicon data analysis methods used in microbiome studies

BACKGROUND: There is an immense scientific interest in the human microbiome and its effects on human physiology, health, and disease. A common approach for examining bacterial communities is high-throughput sequencing of 16S rRNA gene hypervariable regions, aggregating sequence-similar amplicons int...

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發表在:Microbiome
Main Authors: Thorsen, Jonathan, Brejnrod, Asker, Mortensen, Martin, Rasmussen, Morten A., Stokholm, Jakob, Al-Soud, Waleed Abu, Sørensen, Søren, Bisgaard, Hans, Waage, Johannes
格式: Artigo
語言:Inglês
出版: BioMed Central 2016
主題:
Methodology
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC5123278/
https://ncbi.nlm.nih.gov/pubmed/27884206
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40168-016-0208-8
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