Large-scale benchmarking reveals false discoveries and count transformation sensitivity in 16S rRNA gene amplicon data analysis methods used in microbiome studies

BACKGROUND: There is an immense scientific interest in the human microbiome and its effects on human physiology, health, and disease. A common approach for examining bacterial communities is high-throughput sequencing of 16S rRNA gene hypervariable regions, aggregating sequence-similar amplicons int...

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Dades bibliogràfiques
Publicat a:Microbiome
Autors principals: Thorsen, Jonathan, Brejnrod, Asker, Mortensen, Martin, Rasmussen, Morten A., Stokholm, Jakob, Al-Soud, Waleed Abu, Sørensen, Søren, Bisgaard, Hans, Waage, Johannes
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2016
Matèries:
Methodology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5123278/
https://ncbi.nlm.nih.gov/pubmed/27884206
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40168-016-0208-8
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