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Odorant-sensitive adenylate cyclase: rapid, potent activation and desensitization in primary olfactory neuronal cultures.

Using primary olfactory neuronal cultures, we have demonstrated rapid, potent increases in cAMP levels and adenylate cyclase [AC; ATP pyrophosphate-lyase (cyclizing), EC 4.6.1.1] activity in response to odorants. Isobutyl-methoxypyrazine is active at 1 nM. Odorant enhancement is dependent on Ca2+ co...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Ronnett, G V, Parfitt, D J, Hester, L D, Snyder, S H
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 1991
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC51232/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2006174/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.88.6.2366
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