PPFIA1 drives active α5β1 integrin recycling and controls fibronectin fibrillogenesis and vascular morphogenesis

Basolateral polymerization of cellular fibronectin (FN) into a meshwork drives endothelial cell (EC) polarity and vascular remodelling. However, mechanisms coordinating α5β1 integrin-mediated extracellular FN endocytosis and exocytosis of newly synthesized FN remain elusive. Here we show that, on Ra...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:Nat Commun
Päätekijät: Mana, Giulia, Clapero, Fabiana, Panieri, Emiliano, Panero, Valentina, Böttcher, Ralph T., Tseng, Hui-Yuan, Saltarin, Federico, Astanina, Elena, Wolanska, Katarzyna I., Morgan, Mark R., Humphries, Martin J., Santoro, Massimo M., Serini, Guido, Valdembri, Donatella
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Nature Publishing Group 2016
Aiheet:
Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC5122980/
https://ncbi.nlm.nih.gov/pubmed/27876801
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms13546
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