Increased Set1 binding at the promoter induces aberrant epigenetic alterations and up-regulates cyclic adenosine 5'-monophosphate response element modulator alpha in systemic lupus erythematosus

BACKGROUND: Up-regulated cyclic adenosine 5'-monophosphate response element modulator α (CREMα) which can inhibit IL-2 and induce IL-17A in T cells plays a critical role in the pathogenesis of systemic lupus erythematosus (SLE). This research aimed to investigate the mechanisms regulating CREMα...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Clin Epigenetics
Main Authors: Zhang, Qing, Ding, Shu, Zhang, Huilin, Long, Hai, Wu, Haijing, Zhao, Ming, Chan, Vera, Lau, Chak-Sing, Lu, Qianjin
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2016
Teme:
Research
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5122196/
https://ncbi.nlm.nih.gov/pubmed/27904655
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13148-016-0294-2
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